Publications:

Zon LI, Kieran M, Paw B, Thompson M, Guo W, Ransom D, Brownlie A, Chan FY, Barone L, McClennan H, Ziegler S, Pratt S, and Detrich HWIII. The zebrafish: a new model for studying embryonic hematopoiesis. In: Ontogeny of hematopoiesis. Aplastic anemia (E. Gluckman, L. Coulombel, editors). Colloque INSERM/John Libbey Eurotext, Paris, 1995; 235: pp 17-22.

Zon LI. Developmental biology of hematopoiesis. Blood 1995; 86:2876-2891.

Stainier DYR, Weinstein BM, Detrich III HW, Zon LI, Fishman MC. Cloche, a zebrafish gene required for normal vasculogenesis and hematopoiesis, provides evidence for a common progenitor. Development 1995; 121:3141-3150.

Detrich HW, Kieran MW, Chan FY, Barone LM, Yee K, Rundstadler JA, Pratt S, Ransom D, and Zon LI. Intra-embryonic hematopoietic cell migration during vertebrate development. Proc Natl Acad Sci USA 1995; 92:10713-10717.

Ransom DG, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh RN, Brand M, van Eeden FJM, Furutani-Seiki M, Granato M, Hammerschmidt M, Heisenberg C-P, Jiang Y-J, Kane DA, Mullins MC, anmd Nusslein-Volhard C. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development, 1996; 123:311-319.

Chan F-Y, Robinson J, Brownlie A, Shivdasani RA, Donovan A, Brugnara C, Kim J, Lau B-C, Witkowska E, and Zon LI. Characterization of adult a- and b-globin genes in the zebrafish. Blood, 1997; 89:688-700.

Kishimoto Y, Lee K, Zon LI, Hammerschmidt M, and Schulte-Merker S.  The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.  Development 1997; 124:4457-4466.

Liao EC, Paw BH, Oates AC, Pratt SJ, Postlethwait JH, and Zon LI.  SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish.  Gene Dev 1998; 12:621-626.

Postlethwait JH, Yan Y-L, Gates MA, Horne S, Amores A, Brownlie A, Donovan A, Egan ES, Force A, Gong ZY, Goutel, C, Fritz A, Kelsh R, Knapik E, Liao E, Paw B, Ransom D, Singer A, Thompson M, Abduljabbar TS, Yelick P, Beier D, Joly JS, Larhammar D, Rosa F, Zon LI, Johnson SL, Westerfeild M, and Talbot WS.  Vertebrate genome evolution and the zebrafish gene map.  Nat Genet 1998; 18:345-349.

Thompson MA, Ransom DG, Pratt SJ, MacLennan H, Kieran MW, Detrich HW, Vail B, Huber TL, Paw B, Brownlie AJ, Oates AC, Fritz A, Gates MA, Amores A, Bahary N, Talbot WS, Her H, Beier DR, Postlethwait JH, and Zon LI.   The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis.  Dev Biol 1998; 197:248-269.

Jessen JR, Meng AM, MacFarlane RJ, Paw BH, Zon LI, Smith GR, and Lin S.  Modification of bacterial artificial chromosomes through Chi-stimulated homologous recombination and its application in zebrafish transgenesis.  Proc Natl Acad Sci USA 1998;  95:5121-5126.

Brownlie A, Donovan A, Pratt SJ, Paw BH, Oates AC, Brugnara C, Witkowska HE, Sassa S, and Zon LI.  Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anemia.  Nat Genet 1998; 20:244-250.

Fornzler D, Her H, Knapik EW, Clark M, Lehrach H, Postlethwait JH, Zon LI, and Beier DR.  Gene mapping in zebrafish using single-strand conformation polymorphism (SSCP) analysis.  Genomics 1998; 51:216-222.

Lee K-H, Marden JL, Thompson MS, MacLennan H, Kishimoto Y, Pratt SJ, Schulte-Merker S, Hammerschmidt M, Johnson SL, Postlethwait JH, Beier DC, and Zon LI.  Genetic mapping of zebrafish BMP-2.  Dev Genet 1998; 23:97-103.

Oates AC, Pratt SJ, Brownlie A, Irvine DV, Liao EC, Paw B, Dorian K, Johnson SL, Postlethwait JH, Zon LI, and Wilks AF.  Gene duplication of putative zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns; expression of jak2a is not required for the terminal differentiation of primitive erythroblasts.  Blood 1999, in press.

Oates AC, Wollberg P, Pratt SJ, Paw BH, Johnson SL, Postlethwait JH, Zon LI, and Wilks AF.  Zebrafish stat1 and stat3 are expressed in restricted tissues during embryogenesis; stat1 rescues cytokine signaling in a STAT1 deficient human cell line.  Mech Development 1999, in press.